The third edition of the ASSET Summer School will be held at the National Centre for Diseases Prevention and Health Promotion (CNaPPS) of the Istituto Superiore di Sanità (ISS) in Rome from May 30 to June 1, 2017. Pandemics (or more in general public health emergencies of international concern, PHEIC) as well as other major infectious disease outbreaks management do necessarily require a multidisciplinary approach. The ASSET Summer School focuses on
The third issue of the ASSET Paper Series focuses on some highly delicate topics that lie at the intersection of science, ethics, politics, and economics. In the first article of the collection, Donato Greco, epidemiologist and public health expert, discusses about the role and the management of national borders when dealing with both the spread of an infectious disease and the flow of migrants or refugees, citing the recent EU decision on such a matter.
In the context of a Europe increasingly hesitant about vaccination, with dropping vaccination coverage,Immuniser Lyon was a French campaign aiming to re-inform the population of the greater Lyon area in centre-east of France, of the proven benefits of vaccination and to incite people of all ages (children, adults, seniors) to be up-to-date with their vaccinations.
The fact that some vaccine preventable diseases have disappeared or are very rare following these vaccination programs can lead to parents believing there is no more need to vaccinate. Therefore, it is of huge importance that events like the European Immunization, helping maintain vaccination awareness and giving accurate and understandable information on immunization, exist. In this way, public confidence in immunization is less susceptible to be influenced by groups, websites or campaigns against vaccination. By acknowledging that every child deserves a healthy start in life, countries can use the European Immunization Week to increase awareness of the importance of immunization and to strengthen their immunization systems.
Immunization rates in Italy are decreasing at a worrying trend: international targets for measles eradication and safety thresholds in childhood vaccination are vanishing. Authorities, doctors and families are concerned that a coverage below 86% for MPR (measles, parotitis and rubella) vaccine can impair herd immunity, putting younger babies, immunocompromised people and not-responders at risk.
Most emerging diseases come from animals (zoonosis). Therefore, surveillance needs to keep an eye on viruses and other microorganisms that could be transmitted to humans, acquiring the capability to spread among people. Ilaria Capua, director of the One Health Excellence Centre at the Emerging Pathogens Institute of the University of Florida, USA, recommends not letting our guard down.
Ilaria Capua, as director of the One Health Excellence Centre at the Emerging Pathogens Institute of the University of Florida, USA, is very busy in coordinating interdisciplinary research, facing the epidemic of zika virus disease spreading in South America and the Caribbean and reaching Florida. Scientists are testing new diagnostic tests and working on vaccines, but the risk of serious birth defects in the offspring of infected pregnant women calls also for responsible procreative choices, involving lawmakers, governments and religious leaders as well.
Internationally, the issue of including women in clinical trials of medicines has been addressed in various guidelines issued by the International Conference on Harmonization (ICH), which promotes regulatory standards for clinical trials. While ICH has specific guidelines on the conduct of clinical trials in paediatric and geriatric populations, there are no consolidated guidelines for the investigation of medicinal product in women.
Since the thalidomide tragedy in the late1950s, there has been a reluctance to include women of childbearing age in clinical trials. However, this fear cannot be used as an excuse to not include females in clinical trials, and, with proper care and regulation, increased female participation has been reached. The United States adopted regulation early on to increase the participation of women, while a new regulation in Europe is going to improve this as well. Here follows an overview of the issue in Canada and in the USA. The third part of this series will deal with new regulation in Europe.
An increasing perception of the importance of gender differences is moving scientists to study these aspects in the different branches of medicine. In immunology, for example, a new awareness is emerging that women and men’s defences do not react to infections and vaccines in the same way. Katie Flanagan, senior lecturer of the Department of Immunology at Monash University, in Melbourne, Australia, tells ASSET what is the state-of-the-art knowledge and evidence in this field so far.
